What causes syphilis
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Last updated: April 4, 2026
Key Facts
- Syphilis is caused by the bacterium *Treponema pallidum*.
- It is transmitted through direct contact with a syphilis sore (chancre).
- Transmission most commonly occurs during vaginal, anal, or oral sex.
- Syphilis can be passed from a pregnant person to their baby during pregnancy or childbirth.
- Untreated syphilis progresses through distinct stages, each with different symptoms.
What Causes Syphilis?
Syphilis is a sexually transmitted infection (STI) that is caused by a specific type of bacterium known as Treponema pallidum. This microscopic organism is spiral-shaped and thrives in warm, moist environments, making the human body its ideal habitat. The transmission of syphilis is almost exclusively through direct physical contact with an open syphilis sore, or chancre. These sores are typically painless, especially in the early stages, which can make them go unnoticed.
How Syphilis Spreads
The primary mode of transmission for syphilis is through sexual contact. This includes vaginal, anal, and oral sex. When an infected person comes into direct contact with the mucous membranes or skin of an uninfected person, the bacterium can enter the body.
- Vaginal Sex: Contact with a chancre on the penis, vagina, or vulva can lead to infection.
- Anal Sex: Contact with a chancre in the anus or rectum can lead to infection.
- Oral Sex: Contact with a chancre on the mouth, lips, or throat can lead to infection.
It is important to note that syphilis cannot be spread through casual contact such as hugging, kissing, dancing, or sharing toilets, eating utensils, or clothing. The bacterium is fragile and cannot survive for long outside the human body.
Congenital Syphilis
Syphilis can also be transmitted from an infected pregnant person to their fetus during pregnancy or during childbirth. This is known as congenital syphilis. If left untreated, congenital syphilis can lead to serious health problems for the baby, including premature birth, stillbirth, low birth weight, and lifelong health issues such as developmental delays, blindness, deafness, and even death.
The Stages of Syphilis
Syphilis progresses through several stages if left untreated, and each stage is characterized by different symptoms and potential for transmission:
- Primary Syphilis: This is the earliest stage, marked by the appearance of a chancre. The sore usually appears at the site where the syphilis bacteria entered the body, typically 10 to 90 days (an average of 21 days) after exposure. The chancre is often firm, round, small, and painless. It typically heals on its own within 3 to 6 weeks, regardless of whether treatment is received. However, the infection remains in the body.
- Secondary Syphilis: This stage begins when a rash appears on one or more areas of the body, often starting on the trunk of the body and spreading to the palms of the hands and soles of the feet. The rash may not be itchy and can be subtle. Other symptoms can include fever, swollen lymph nodes, sore throat, patchy hair loss, headaches, weight loss, muscle aches, and fatigue. These symptoms can resolve on their own within a few weeks to months, but the infection is still present.
- Latent Syphilis: This is a stage where there are no visible signs or symptoms of the infection. It can last for years. The infection is still present in the body, but it is not actively causing symptoms. Early latent syphilis is defined as infection acquired within the past 12 months, while late latent syphilis is infection acquired more than 12 months ago.
- Tertiary Syphilis: This is the most severe stage and can occur 10 to 30 years after the initial infection. In this stage, the infection can cause severe damage to internal organs, including the heart, brain, nerves, eyes, liver, bones, and joints. Complications can include neurosyphilis (affecting the brain and nervous system) and cardiovascular syphilis (affecting the heart and aorta). Tertiary syphilis can be debilitating and life-threatening.
Diagnosis and Treatment
Syphilis is diagnosed through a physical examination and laboratory tests, including blood tests and examination of fluid from a chancre. Fortunately, syphilis is curable with antibiotics, most commonly penicillin. The effectiveness of treatment depends on the stage of the infection. Early stages are generally easier to treat and have a higher chance of complete recovery. It is crucial to seek medical attention if you suspect you have syphilis or have been exposed to someone with the infection.
Prevention
The most effective way to prevent syphilis is to practice safe sex. This includes using condoms consistently and correctly during vaginal, anal, and oral sex. Regular STI testing, especially if you have multiple partners or engage in high-risk sexual behaviors, is also essential for early detection and treatment.
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Sources
- Syphilis - CDCfair-use
- Syphilis - WHOfair-use
- Syphilis - WikipediaCC-BY-SA-4.0
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